Combinatorial biomedicine: A novel discipline (preprint)

Based on the author’s previous work, this article proposed a novel discipline– combinatorial biomedicine. Currently, there are several classical examples. One is a magic “polypill” covering the “Health Essential (HE) 5”, that is, “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] lifestyle; Another is an innovative “traditional Chinese medicine (TCM) Hot Pot”. In addition, the iRT-ABCDEFG program is indeed suitable for better management of human diseases. In fact, combinatorial biomedicine is pivotal in the development of life science, biology and medicine, in particular the pandemic and post-COVID-19 era, and has obvious advantages in screening, diagnosis, treatments, prevention and rehabilitation of both major non-communicable diseases (such as cardiovascular disease, diabetes, cancer, stroke, and neurodegenerative diseases) and major infectious diseases (such as AIDS, Helicobacter pylori infection, and COVID-19). As a novel discipline, combinatorial biomedicine plays a crucial role in combating human diseases and improving population health. It is about time to propose and establish this novel discipline.

Ocean & seas: Novel biomedical resources for anti-infection of SARS-CoV-2 (preprint)

This article briefly reviews ocean and seas as huge and novel biomedical resources for anti-infection, which includes tuberculosis, H. Pylori, and HIV infection as well as SARS-CoV-2, and as promising biomedical resources for infection-induced major non-communicable diseases (mNCDs), such as cardiovascular disease, diabetes, and cancer. These marine natural products (MNPs) and organisms include sea cucumbers, sea snake, sponge, marine algae and microalgae, etc. As key biomedical resources for the discovery of marine drugs, bioactive molecules, and agents for treatment of infectious diseases and mNCDs, MNPs have bioactive potentials of antioxidant, anti-infection, anti-inflammatory, anticoagulant, anti-diabetic effects, and cancer treatment. In addition, their anti-inflammatory mechanisms for infectious diseases are also involved. It’s time to protect ocean ecosystem for human better sustainable development in the new era of ocean economy.

Marine natural products and human immunity: Novel biomedical resources for anti-infection of SARS-CoV-2 and related cardiovascular disease (preprint)

Major marine natural products (MNPs) and marine organisms include sea urchin, sea squirts or ascidians, sea cucumbers, sea snake, sponge, soft coral, marine algae, and microalgae. As vital biomedical resources for the discovery of marine drugs, bioactive molecules, and agents for treatment of infectious diseases and major non-communicable diseases (mNCDs), these MNPs have bioactive potentials of antioxidant, anti-infection, anti-inflammatory, anticoagulant, anti-diabetic effects, cancer treatment, and improvement of human immunity. This article reviews MNPs as huge and novel biomedical resources for anti-infection of coronavirus (SARS-CoV-2 and its variants), as well tuberculosis, H. Pylori, and HIV infection, and as promising biomedical resources for SARS-CoV-2 infection related cardiovascular disease (irCVD), and other mNCDs, such as diabetes and cancer. In addition, the anti-inflammatory mechanisms of current MNPs against SARS-CoV-2 infection which link to human immunity are also involved. It’s time to protect this ecosystem for human better sustainable development in the new era of ocean economy.

A new “single” era of biomedicine: Applications in cardiovascular disease and COVID-19 (preprint)

With the development of cellular, chemical, and molecular biology, such as, single-cell, single-molecule, single-nucleus, single-chromosome and other related biotechnologies for analysis of chromatin regions, and under the help of single-nucleus and single-cell transcriptomics of human diseases in cardiovascular system, there are many novel breakthroughs in the field of life science and medicine. It can be said that a new “single” era of biomedicine comes. As transforming medical research tools at single-cell levels, single-cell technologies including single-cell RNA sequencing (scRNA-seq) provide high-resolutions insight into complex tissues covered cardiovascular and brain systems, they can help to understand molecular mechanisms of both COVID-19 and cardiovascular disease (CVD), such as atherosclerosis (AS), acute myocardial infarction (AMI), arrhythmogenic cardiomyopathy (ACM), inherited thoracic aortic aneurysm (iTAA) or ascending thoracic aortic aneurysm (ATAA), calcific aortic valve disease, heart failure, and others as well as develop novel therapeutic targets and approaches relevant for CVD and COVID-19.

Emerging protective measures and strategies of COVID-19: From lifestyle to traditional Chinese medicine (preprint)

This article introduces current status of COVID-19 and its side-effects, and reviews emerging protective measures and strategies from lifestyle to traditional Chinese medicine (TCM) for fighting against the SARS-CoV-2 and its major variants (Delta and Omicron) as well as the global COVID-19 pandemic, which include “Carassius auratus lifestyle” for high effective isolation, social and high-tech related medical strategies, traditional Chinese herbs “Bark-Flower-Fruit-Grass-Leaf-Nucleolus-Root (BFFGLNR)”, as well the combination of Chinese and western medicine. As a choice, little is known whether Chinese acupuncture is an effective method for confirmed and suspected COVID-19 patients, which include imported and asymptomatic cases. Definitely, acupuncture is effective for the recovery of COVID-19 cases. However, its effects and related mechanisms need further animal experiments and clinical trials to confirm and disclose. In conclusion, these emerging protective measures and strategies for COVID-19 will help to effectively combat the SARS-CoV-2 and its variants during the pandemic and post-COVID-19 era.

Cardiovascular protection in the pandemic and post-COVID-19 era (preprint)

This article introduces briefly current status of the Covid-19 pandemic and discusses “antidotes” of coronavirus (SARS-CoV-2 and its variants), that is, “ISISI” barriers from locals, nations or regions to the globe, namely, [Isolation with Masks, Unit protective clothing, Stay at “home”, and Travel restriction (MUST); Screening and testing; Individual immunity by healthy E(e)SEEDi lifestyle, bio-agents (chemical agents, convalescent plasma, neutralizing antibody, and Chinese medicine), and vaccination; Social and medical supports; International cooperation and information sharing]. Since there are several major coronavirus variants with more infectious, such as Delta and Omicron, many more cases with cardiac injury and cardiac arrest need better cardiovascular prevention and protection. With further understanding of the pathogenesis of Covid-19 and development of novel mRNA vaccines and discovery of new antiviral drugs, such as Molnupiravir and Paxlovid, people will do better in fighting against SARS-CoV-2 and its variants and cardiovascular protection in the pandemic and post-Covid-19 era.

Combating COVID-19 for human cardiovascular health: From “ISISI” strategies to final victory (preprint)

The COVID-19 pandemic is still continuing. Current major variants of SARS-CoV-2 (Delta and Omicron) have lead to new uncertainties. Since the infection of SARS-CoV-2 and its major variants has been a high risk factor of cardiovascular health due to major adverse cardiovascular events (MACCE) and outcomes. Thus, the more coverage of vaccination, enough health workers, and related medical resources as well as the “ISISI” barriers from locals or regions to the globe play a critical role in combating COVID-19 and protection of human cardiovascular health.

A novel comprehensive program combined optimal medical treatment and lifestyle for type 2 diabetes (preprint)

This article introduces briefly current status in managing type 2 diabetes (T2D) and an updated classical standardized comprehensive program which combines optimal medical treatment (OMT) with lifestyle modification, that is, intervention of RT-ABCDEFG (iRT-ABCDEFG) for control and prevention of T2D, and discusses its advantages and prospects. Here, G means goals; F means follow-up; E means examination; D means disease & risk factors control; C means changing unhealthy “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] lifestyle & Chinese medicine or control the source of infection & cutting genetic or spreading pathways during the COVID-19 pandemic; B means biohazard control; And A means antagonistic treatment, such as optimal anti-diabetic agents, the glucagon-like peptide-1 receptor (GLPR) agonists, the sodium-glucose cotransporter 2 (SGLT2) inhibitors, and the ultralong-acting, once-daily basal insulin. As a novel strategy for Intervention of diabetes, this program can be used as a Reverse, Right, and Routine Treatment in clinical practice. Moreover, the vital goals which include less major adverse cardiocerebrovascular events (MACCE) and diabetic complications, less medical costs, longer life expectancy, lower morbidity and mortality, and higher quality of life, will be realized by consistently practicing this program due to early diagnosis, OMT, and overall prevention. Whatever, this program is very helpful to manage or self-manage T2D and improve its outcomes since it highly links to cardiovascular disease (CVD), stroke, cancer, and other MACCEs.